Plant Transcription Factor Database
Previous version: v3.0
Oryza glaberrima
HD-ZIP Family
Species TF ID Description
ORGLA08G0159100.1HD-ZIP family protein
ORGLA08G0128600.1HD-ZIP family protein
ORGLA02G0266600.1HD-ZIP family protein
ORGLA09G0102600.1HD-ZIP family protein
ORGLA04G0178100.1HD-ZIP family protein
ORGLA08G0152800.1HD-ZIP family protein
ORGLA03G0062800.1HD-ZIP family protein
ORGLA10G0080300.1HD-ZIP family protein
ORGLA03G0050600.1HD-ZIP family protein
ORGLA02G0180800.1HD-ZIP family protein
ORGLA10G0001600.1HD-ZIP family protein
ORGLA10G0137100.1HD-ZIP family protein
ORGLA10G0067800.1HD-ZIP family protein
ORGLA04G0173700.1HD-ZIP family protein
ORGLA03G0089600.1HD-ZIP family protein
ORGLA06G0025500.1HD-ZIP family protein
ORGLA06G0025700.1HD-ZIP family protein
ORGLA02G0222500.1HD-ZIP family protein
ORGLA01G0196200.1HD-ZIP family protein
ORGLA06G0218000.1HD-ZIP family protein
ORGLA07G0257600.1HD-ZIP family protein
ORGLA02G0035900.1HD-ZIP family protein
ORGLA03G0069400.1HD-ZIP family protein
ORGLA08G0042800.1HD-ZIP family protein
ORGLA04G0231200.1HD-ZIP family protein
ORGLA08G0016400.1HD-ZIP family protein
ORGLA02G0238300.1HD-ZIP family protein
ORGLA01G0257700.1HD-ZIP family protein
ORGLA03G0253300.1HD-ZIP family protein
ORGLA12G0158900.1HD-ZIP family protein
ORGLA03G0005300.1HD-ZIP family protein
ORGLA10G0115700.1HD-ZIP family protein
ORGLA06G0063600.1HD-ZIP family protein
ORGLA04G0191300.1HD-ZIP family protein
ORGLA10G0146400.1HD-ZIP family protein
ORGLA06G0247800.1HD-ZIP family protein
ORGLA08G0080600.1HD-ZIP family protein
ORGLA01G0275300.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401